55511-85-8
55511-85-8
Chemical Structure
11-Demethyltomaymycin
- CAS No.: 55511-85-8
- Formula:C15H18N2O4
- Molecular Weight:290.31
InChIKey: QUYGRHFKOMIUQW-CYXMTJDRSA-N
SMILES: O=C1N2[C@](C/C(C2)=C\C)([H])[C@H](NC3=CC(O)=C(OC)C=C31)O
Biological Activity: 11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T1 and T3 phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells[1][2].
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11-Demethyltomaymycin | 11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T1 and T3 phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells. | |||||||||||||||||||||
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References
- [1]. Hurley LH, et al. Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes. Biochemistry. 1976 Aug 24;15(17):3760-9. [Content Brief]
- [2]. Hurley L H, et al. Biosynthesis of the antiviral antibiotic 11-demethyltomaymycin by Streptomyces achromogenes. Journal of the Chemical Society, Chemical Communications, 1975 (4): 120-121.
