57-08-9
Chemical Structure
6-Acetamidohexanoic acid
Synonym(s): Acexamic acid; 6-Acetamidocaproic acid
- CAS No.: 57-08-9
- Formula:C8H15NO3
- Molecular Weight:173.21
IUPAC Name: 6-acetamidohexanoic acid
InChIKey: WDSCBUNMANHPFH-UHFFFAOYSA-N
SMILES: O=C(O)CCCCCNC(C)=O
Biological Activity: 6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer[1][2][3].
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6-Acetamidohexanoic acid | 98.0% | 6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer. | ||||||||||||||||||||
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6-Acetamidohexanoic acid (Standard) | ≥98% | 6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) (Standard) is the analytical standard of 6-Acetamidohexanoic acid. This product is intended for research and analytical applications. 6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer. | ||||||||||||||||||||
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[1]. Daoudal P, et al. Hypoxémies dites réfractaires: traitement par acide acéxamique [So-called refractory hypoxemia: treatment with acexamic acid]. Nouv Presse Med. 1979 Dec 3;8(47):3899. French. PMID: 95046.
[Content Brief] - [2]. Li L, et al. A carboxylesterase-activatable near-infrared phototheranostic probe for tumor fluorescence imaging and photodynamic therapy. RSC Adv. 2022;12(54):35477-35483. Published 2022 Dec 12. [Content Brief]
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[3]. Harpalani AD, et al. Alkylamides as inducers of human leukemia cell differentiation: a quantitative structure-activity relationship study using comparative molecular field analysis. Cancer Res. 1993 Feb 15;53(4):766-71. PMID: 8428356.
[Content Brief]
