57558-44-8
Chemical Structure
Secoverine
- CAS No.: 57558-44-8
- Formula:C22H35NO2
- Molecular Weight:345.52
InChIKey: WAVYHSURRZBQKO-UHFFFAOYSA-N
SMILES: O=C(C1CCCCC1)CCCN(C(CC2=CC=C(C=C2)OC)C)CC
Biological Activity: Secoverine is a muscarinic cholinergic receptor (mAChR) antagonist and antispasmodic with blood-brain barrier permeability. Secoverine binds competitively to muscarinic receptors, blocks central cholinergic effects, and inhibits cholinergically induced gastrointestinal motility, intestinal smooth muscle contraction, and acetylcholine-mediated neurotransmitter release. Secoverine exerts direct antispasmodic activity on intestinal smooth muscle independent of receptor blockade, and exhibits characteristics such as reversible smooth muscle activity and long duration of action. Secoverine can be used in studies related to hyperintestinal motility, diverticular disease, and colonic spasm[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Secoverine | Secoverine is a muscarinic cholinergic receptor (mAChR) antagonist and antispasmodic with blood-brain barrier permeability. Secoverine binds competitively to muscarinic receptors, blocks central cholinergic effects, and inhibits cholinergically induced gastrointestinal motility, intestinal smooth muscle contraction, and acetylcholine-mediated neurotransmitter release. Secoverine exerts direct antispasmodic activity on intestinal smooth muscle independent of receptor blockade, and exhibits characteristics such as reversible smooth muscle activity and long duration of action. Secoverine can be used in studies related to hyperintestinal motility, diverticular disease, and colonic spasm. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Greenwood B, et al. Effect of secoverine and atropine on intestinal secretion and motor activity in the rat small intestine in-vivo. The Journal of pharmacy and pharmacology. 1984 Feb;36(2):100-6. [Content Brief]
- [2]. Zwagemakers JM, et al. Secoverine selectively antagonizes muscarinic effects in various in vivo preparations. European journal of pharmacology. 1981 Apr 24;71(1):165-8. [Content Brief]
- [3]. Brunner F, et al. Secoverine is a non-selective muscarinic antagonist on rat heart and brain receptors. European journal of pharmacology. 1986 Aug 07;127(1-2):17-25. [Content Brief]
Keywords
