57801-95-3
57801-95-3
Chemical Structure
Flubrotizolam
- CAS No.: 57801-95-3
- Formula:C15H10BrFN4S
- Molecular Weight:377.23
InChIKey: VOZDBDBHBXLWCG-UHFFFAOYSA-N
SMILES: FC1=C(C2=NCC3=NN=C(C)N3C4=C2C=C(Br)S4)C=CC=C1
Biological Activity: Flubrotizolam is a GABA-A receptor modulator. Flubrotizolam allosterically enhances GABA-induced chloride currents at α1β2γ2 GABA-A receptors through the benzodiazepine binding interface, an effect that is abolished by Flumazenil (HY-B0009). Flubrotizolam undergoes limited metabolism in human hepatocytes, primarily generating metabolites via hydroxylation and glucuronidation[1][2][3].
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Flubrotizolam | 98.64% | Flubrotizolam is a GABA-A receptor modulator. Flubrotizolam allosterically enhances GABA-induced chloride currents at α1β2γ2 GABA-A receptors through the benzodiazepine binding interface, an effect that is abolished by Flumazenil (HY-B0009). Flubrotizolam undergoes limited metabolism in human hepatocytes, primarily generating metabolites via hydroxylation and glucuronidation. | ||||||||||||||||||||
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References
- [1]. Gameli PS, et al. Exploring the Metabolism of Flubrotizolam, a Potent Thieno-Triazolo Diazepine, Using Human Hepatocytes and High-Resolution Mass Spectrometry. Metabolites. 2024 Sep 19;14(9):506.
- [2]. Norman C, et al. In vitro γ-aminobutyric acid A (GABA) receptor activity and binding interactions at the α/γ interface of 53 prescription and designer benzodiazepines. Communications chemistry. 2026 Apr 07;9(1):155.
- [3]. Catalani V, et al. In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines. Chemical biology & drug design. 2023 Jan;101(1):40-51. [Content Brief]
