583868-50-2
Chemical Structure
MOL-6131
- CAS No.: 583868-50-2
- Formula:C43H48N8O5
- Molecular Weight:756.89
IUPAC Name: N-(4-(aminomethyl)benzyl)-8-(1-(4-(2-(4-aminophenyl)acetamido)butanoyl)piperidin-4-yl)-2-(naphthalen-1-ylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxamide
InChIKey: NLOQJUMFADVDAI-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=C(C=C1)N)NCCCC(N2CCC(C3C=CC(N4C(N(CC5=CC=CC6=C5C=CC=C6)C(N43)=O)=O)C(NCC7=CC=C(CN)C=C7)=O)CC2)=O
Biological Activity: MOL-6131 is a highly selective, reversible tryptase inhibitor, with a Ki of 45 nM. MOL-6131 significantly reduces the following features of allergic airway inflammation: eosinophil infiltration in lung tissue, goblet cell hyperplasia and mucus occlusion of airways[1].
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MOL-6131 | MOL-6131 is a highly selective, reversible tryptase inhibitor, with a Ki of 45 nM. MOL-6131 significantly reduces the following features of allergic airway inflammation: eosinophil infiltration in lung tissue, goblet cell hyperplasia and mucus occlusion of airways. | |||||||||||||||||||||
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