58433-11-7
Chemical Structure
Tilomisole
Synonym(s): Wy 18251
- CAS No.: 58433-11-7
- Formula:C17H11ClN2O2S
- Molecular Weight:342.80
IUPAC Name: 2-(3-(4-chlorophenyl)benzo[4,5]imidazo[2,1-b]thiazol-2-yl)acetic acid
InChIKey: PUYFLGQZLHVTHX-UHFFFAOYSA-N
SMILES: O=C(CC1=C(C2=CC=C(Cl)C=C2)N3C4=C(C=CC=C4)N=C3S1)O
Biological Activity: Tilomisole (Wy 18251) is a benzimidazothiazole experimental agent with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].
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Tilomisole | Tilomisole (Wy 18251) is a benzimidazothiazole experimental agent with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation. | |||||||||||||||||||||
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- [1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14. [Content Brief]
- [2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644. [Content Brief]
Keywords
