5852-92-6
Chemical Structure
Carnegine hydrochloride
- CAS No.: 5852-92-6
- Formula:C13H20ClNO2
- Molecular Weight:257.76
IUPAC Name: 6,7-dimethoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
InChIKey: LARXMHOYLNCTFD-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(C(C)N(CC2)C)=C1)OC.Cl
Biological Activity: Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system[1][2].
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Carnegine hydrochloride | Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system. | |||||||||||||||||||||
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References
- [1]. Bouaziz A, Mhalla D, Zouari I, et al. Antibacterial and antioxidant activities of Hammada scoparia extracts and its major purified alkaloids[J]. South African Journal of Botany, 2016, 105: 89-96.
- [2]. Bracca A B J, Kaufman T S. Synthetic approaches to carnegine, a simple tetrahydroisoquinoline alkaloid[J]. Tetrahedron, 2004, 60(47): 10575-10610.
