Carnegine hydrochloride
Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system.
For research use only. We do not sell to patients.
- CAS No.: 5852-92-6
- Formula: C13H20ClNO2
- Molecular Weight:257.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MAO-A |
MAO-B |
Carnegine hydrochloride exhibits no DPPH radical scavenging activity in vitro[1].
Carnegine hydrochloride weakly inhibits β-carotene bleaching with 39.35% activity in vitro[1].
Carnegine hydrochloride (90 min) has a very low total antioxidant capacity of 0.69 mg BHT eq/100 g in the phosphomolybdenum assay in vitro[1].
Carnegine hydrochloride (24 h) inhibits the growth of multiple Gram-positive and Gram-negative bacteria in agar diffusion assays, with inhibition zone diameters ranging from 10 to 18 mm in vitro[1].
Carnegine hydrochloride (0.125-2 mg/mL (MIC); 0.25-2 mg/mL (MBC); 24 h) shows bactericidal activity against multiple Gram-positive and Gram-negative bacteria with MIC values ranging from 0.125 to 0.5 mg/mL and MBC values ranging from 0.25 to 2 mg/mL in vitro[1].
Carnegine hydrochloride (0.5-4 mg/mL; 0-60 min) exhibits concentration-dependent rapid bactericidal activity against Staphylococcus aureus ATCC 25923 in vitro, with complete killing at 4 mg/mL within 20 min and 4 log CFU/mL reduction at 1 mg/mL within 60 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Carnegine hydrochloride (0.5-2 mg/kg; i.v.; single dose) induces hypotension in dogs, while 1 and 2 mg/kg intravenously additionally increases respiratory rate and amplitude[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[2]
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Dosage:15 mg/kg
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Administration:i.p.; single dose
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Result:Reached an intraperitoneal LD50 of approximately 15 mg/kg.
Induced strychnine-like tonic-clonic convulsions affecting the central nervous system.
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Animal Model:Dog[2]
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Dosage:0.5 mg/kg; 1 mg/kg; 2 mg/kg
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Administration:i.v.; single dose
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Result:Produced a hypotensive effect at 0.5 mg/kg administered intravenously.
Produced a hypotensive effect and stimulated the rate and amplitude of respiration at 1 mg/kg and 2 mg/kg intravenously.
Chemical Information
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CAS No. 5852-92-6
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Molecular Weight 257.76
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Formula C13H20ClNO2
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SMILES
COC1=C(C=C2C(C(C)N(CC2)C)=C1)OC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carnegine hydrochloride Related Classifications
HY-W676530 Related Classifications
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