Carnegine hydrochloride
Carnegine hydrochloride is a fungicide with broad-spectrum antibacterial activity, as well as a stereoselective inhibitor of MAO-A/MAO-B. Carnegine hydrochloride has no antioxidant activity and does not affect cerebral PDE, but it antagonizes the chronotropic effects of adrenaline and noradrenaline at low concentrations and induces tolerance in *Drosophila melanogaster*. Carnegine hydrochloride stimulates respiration, exerts mild spasmolytic and hypotensive effects, inhibits cancer cell respiration, and exhibits central nervous system excitatory toxicity and negative chronotropic effects on the cardiovascular system.
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- CAS No.: 5852-92-6
- 화학식: C13H20ClNO2
- 분자량:257.76
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
IC50 & Target
[1]|
MAO-A |
MAO-B |
In Vitro
Carnegine hydrochloride exhibits no DPPH radical scavenging activity in vitro[1].
Carnegine hydrochloride weakly inhibits β-carotene bleaching with 39.35% activity in vitro[1].
Carnegine hydrochloride (90 min) has a very low total antioxidant capacity of 0.69 mg BHT eq/100 g in the phosphomolybdenum assay in vitro[1].
Carnegine hydrochloride (24 h) inhibits the growth of multiple Gram-positive and Gram-negative bacteria in agar diffusion assays, with inhibition zone diameters ranging from 10 to 18 mm in vitro[1].
Carnegine hydrochloride (0.125-2 mg/mL (MIC); 0.25-2 mg/mL (MBC); 24 h) shows bactericidal activity against multiple Gram-positive and Gram-negative bacteria with MIC values ranging from 0.125 to 0.5 mg/mL and MBC values ranging from 0.25 to 2 mg/mL in vitro[1].
Carnegine hydrochloride (0.5-4 mg/mL; 0-60 min) exhibits concentration-dependent rapid bactericidal activity against Staphylococcus aureus ATCC 25923 in vitro, with complete killing at 4 mg/mL within 20 min and 4 log CFU/mL reduction at 1 mg/mL within 60 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Carnegine hydrochloride (0.5-2 mg/kg; i.v.; single dose) induces hypotension in dogs, while 1 and 2 mg/kg intravenously additionally increases respiratory rate and amplitude[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[2]
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Dosage:15 mg/kg
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Administration:i.p.; single dose
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Result:Reached an intraperitoneal LD50 of approximately 15 mg/kg.
Induced strychnine-like tonic-clonic convulsions affecting the central nervous system.
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Animal Model:Dog[2]
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Dosage:0.5 mg/kg; 1 mg/kg; 2 mg/kg
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Administration:i.v.; single dose
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Result:Produced a hypotensive effect at 0.5 mg/kg administered intravenously.
Produced a hypotensive effect and stimulated the rate and amplitude of respiration at 1 mg/kg and 2 mg/kg intravenously.
Chemical Information
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CAS No. 5852-92-6
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분자량 257.76
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화학식 C13H20ClNO2
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SMILES
COC1=C(C=C2C(C(C)N(CC2)C)=C1)OC.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)