58919-61-2
Chemical Structure
Coprine
- CAS No.: 58919-61-2
- Formula:C8H14N2O4
- Molecular Weight:202.21
IUPAC Name: N5-(1-hydroxycyclopropyl)-L-glutamine
InChIKey: OEEZRBUCLFMTLD-YFKPBYRVSA-N
SMILES: OC([C@@H](N)CCC(NC1(CC1)O)=O)=O
Biological Activity: Coprine is an orally active disulfiram (HY-B0240)-like component and an inhibitor of aldehyde dehydrogenase. Coprine is isolated from Coprinus atranentarius. Coprine inhibits low Km aldehyde dehydrogenase in rat liver and increases blood acetaldehyde levels during in vivo ethanol metabolism. Coprine does not inhibit semi-purified low Km aldehyde dehydrogenase from rat liver in vitro. Coprine can be used in studies related to alcoholism[1][2][3].
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Coprine | Coprine is an orally active disulfiram (HY-B0240)-like component and an inhibitor of aldehyde dehydrogenase. Coprine is isolated from Coprinus atranentarius. Coprine inhibits low Km aldehyde dehydrogenase in rat liver and increases blood acetaldehyde levels during in vivo ethanol metabolism. Coprine does not inhibit semi-purified low Km aldehyde dehydrogenase from rat liver in vitro. Coprine can be used in studies related to alcoholism. | |||||||||||||||||||||
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- [1]. Lindberg P, et al. Isolation and structure of coprine, the in vivo aldehyde dehydrogenase inhibitor in Coprinus atramentarius; Syntheses of coprine and related cyclopropa4one derivatives. J Chem Soc Perkin 1. 1977;(6):684-91. [Content Brief]
- [2]. Carlsson A, et al. On the disulfiram-like effect of coprine, the pharmacologically active principle of Coprinus atramentarius. Acta Pharmacol Toxicol (Copenh). 1978;42(4):292-297. [Content Brief]
- [3]. Tottmar O, et al. Effects on rat liver acetaldehyde dehydrogenases in vitro and in vivo by coprine, the disulfiram-like constituent of Coprinus atramentarius. Acta Pharmacol Toxicol (Copenh). 1977;40(4):476-481. [Content Brief]
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