5897-18-7
5897-18-7
Chemical Structure
Cyclizine dihydrochloride
- CAS No.: 5897-18-7
- Formula:C18H24Cl2N2
- Molecular Weight:339.30
IUPAC Name: 1-benzhydryl-4-methylpiperazine dihydrochloride
InChIKey: CKLJCUGYMOMAEJ-UHFFFAOYSA-N
SMILES: CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl
Biological Activity: Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness[1][2][3].
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Cyclizine dihydrochloride | Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness. | |||||||||||||||||||||
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References
- [1]. Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. [Content Brief]
- [2]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7. [Content Brief]
- [3]. Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6. [Content Brief]
Keywords
