Cyclizine dihydrochloride
Cyclizine dihydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine dihydrochloride can be used for the research of nausea, vomiting, and dizziness.
For research use only. We do not sell to patients.
- CAS No.: 5897-18-7
- Formula: C18H24Cl2N2
- Molecular Weight:339.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
H1 Receptor |
In Vitro
Cyclizine (100 μM) dihydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants[1].
Cyclizine dihydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g[3]
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Dosage:1, 10 mg/kg
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Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.
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Result:Enhanced locomotor activity in a dose-dependent manner.
Chemical Information
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CAS No. 5897-18-7
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Molecular Weight 339.30
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Formula C18H24Cl2N2
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SMILES
CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. [Content Brief]
[2]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7. [Content Brief]
[3]. Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22(2):293-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyclizine dihydrochloride Related Classifications
HY-B1397A Related Classifications
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