59170-23-9
Chemical Structure
Bevantolol
Synonym(s): SOM3355 free base
- CAS No.: 59170-23-9
- Formula:C20H27NO4
- Molecular Weight:345.43
IUPAC Name: 1-((3,4-dimethoxyphenethyl)amino)-3-(m-tolyloxy)propan-2-ol
InChIKey: HXLAFSUPPDYFEO-UHFFFAOYSA-N
SMILES: OC(COC1=CC=CC(C)=C1)CNCCC2=CC=C(OC)C(OC)=C2
Biological Activity: Bevantolol (SOM3355 (free base)) is a selective β1-adrenergic receptor antagonist, with an IC50 of 35 nM for β1-adrenergic receptor and an IC50 of 60 nM for VMAT2. Bevantolol blocks β1-adrenergic receptors, exerts partial agonistic effects on α-adrenoceptor, inhibits calcium currents in the sinoatrial and atrioventricular nodes as well as sodium currents in cardiomyocytes, delays repolarization, and shortens the action potential duration of Purkinje cells. Bevantolol reduces peripheral vascular resistance, increases subendocardial blood flow, inhibits VMAT2, elevates the serum HDL/LDL ratio, and does not affect glomerular filtration rate or cause cold extremities. Bevantolol is applicable to research related to angina pectoris, hypertension, arrhythmia, and Huntington's disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bevantolol | 98.19% | Bevantolol (SOM3355 (free base)) is a selective β1-adrenergic receptor antagonist, with an IC50 of 35 nM for β1-adrenergic receptor and an IC50 of 60 nM for VMAT2. Bevantolol blocks β1-adrenergic receptors, exerts partial agonistic effects on α-adrenoceptor, inhibits calcium currents in the sinoatrial and atrioventricular nodes as well as sodium currents in cardiomyocytes, delays repolarization, and shortens the action potential duration of Purkinje cells. Bevantolol reduces peripheral vascular resistance, increases subendocardial blood flow, inhibits VMAT2, elevates the serum HDL/LDL ratio, and does not affect glomerular filtration rate or cause cold extremities. Bevantolol is applicable to research related to angina pectoris, hypertension, arrhythmia, and Huntington's disease. | ||||||||||||||||||||
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References
- [1]. Vaughan Williams EM, et al. Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. Journal of clinical pharmacology. 1987 Jul;27(7):450-60. [Content Brief]
- [2]. Gamez J, et al. A proof-of-concept study with SOM3355 (bevantolol hydrochloride) for reducing chorea in Huntington's disease. British journal of clinical pharmacology. 2023 May;89(5):1656-1664.
- [3]. Dukes ID, et al. Cardiovascular effects of bevantolol, a selective beta 1-adrenoceptor antagonist with a novel pharmacological profile. British journal of pharmacology. 1985 Feb;84(2):365-80. [Content Brief]
