5945-86-8
Chemical Structure
Nimbin
- CAS 番号: 5945-86-8
- Formula:C30H36O9
- Molecular Weight:540.60
IUPAC Name: methyl (2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-acetoxy-2-(furan-3-yl)-10-(2-methoxy-2-oxoethyl)-1,6,9a,10a-tetramethyl-9-oxo-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-2H-cyclopenta[b]naphtho[2,3-d]furan-6-carboxylate
InChIKey: NHOIBRJOQAYBJT-IMGVWCFESA-N
SMILES: C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O
Biological Activity: Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].
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Nimbin | 99.59% | Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin is promising for research of neurodegenerative diseases and viral infections. | ||||||||||||||||||||
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- [1]. Nalini V Gorantla, et al. Neem Derivatives Inhibits Tau Aggregation. J Alzheimers Dis Rep. 2019 Jun 14;3(1):169-178. [Content Brief]
- [2]. P Lavanya, et al. Computational Analysis Reveal Inhibitory Action of Nimbin Against Dengue Viral Envelope Protein. Virusdisease. 2015 Dec;26(4):243-54. [Content Brief]
- [3]. Li-Juan Yang, et al. Host-guest System of Nimbin and Beta-Cyclodextrin or Its Derivatives: Preparation, Characterization, Inclusion Mode, and Solubilization. J Agric Food Chem. 2010 Aug 11;58(15):8545-52. [Content Brief]
- [4]. Sidhu O P, et al. Variability in triterpenoids (nimbin and salanin) composition of neem among different provenances of India[J]. Industrial Crops and Products, 2004, 19(1): 69-75.
Keywords
