59455-93-5
Chemical Structure
TNKS-IN-1
- CAS No.: 59455-93-5
- Formula:C18H18N2O
- Molecular Weight:278.36
IUPAC Name: 2-(4-(tert-butyl)phenyl)quinazolin-4(1H)-one
InChIKey: QTABKBZRAZXDQK-UHFFFAOYSA-N
SMILES: O=C1N=C(NC=2C=CC=CC12)C=3C=CC(=CC3)C(C)(C)C
Biological Activity: TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TNKS-IN-1 | 99.55% | TNKS-IN-1 is a selective and potent tankyrase (TNKS1/TNKS2) inhibitor with IC50 values of 7.9 nM and 8.7 nM. TNKS-IN-1 induces axin2 accumulation with an EC50 of 1500 nM. TNKS-IN-1 can antagonize the Wnt signal transduction pathway by stabilizing axin proteins and promoting β-catenin degradation. TNKS-IN-1 can be used for the research of colorectal cancer. | ||||||||||||||||||||
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Keywords
