5988-76-1
Chemical Structure
Cucurbitacin C
Synonym(s): CuC
- CAS No.: 5988-76-1
- Formula:C32H48O8
- Molecular Weight:560.72
IUPAC Name: (R,E)-6-((3R,8S,9R,10R,13R,14S,16R,17R)-3,16-dihydroxy-9-(hydroxymethyl)-4,4,13,14-tetramethyl-11-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
InChIKey: DGIGXLXLGBAJJN-XOMTXOPZSA-N
SMILES: OC[C@]12[C@](CC=C3[C@@]2([H])CC[C@H](C3(C)C)O)([H])[C@]4([C@](CC1=O)([C@@]([C@@H](C4)O)([H])[C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)C)C
Biological Activity: Cucurbitacin C is a tetracyclic triterpenoid compound. Cucurbitacin C exhibits significant in vivo and in vitro anticancer activity, which inhibits the PI3K/AKT signaling pathway to induce cell cycle arrest and apoptosis in cancer cells, and significantly suppresses the growth of HepG2 and PC-3 xenograft tumors in mice. Cucurbitacin C can be used in studies on plant defense mechanisms, secondary metabolism and cancer therapy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cucurbitacin C | 95.0% | Cucurbitacin C is a tetracyclic triterpenoid compound. Cucurbitacin C exhibits significant in vivo and in vitro anticancer activity, which inhibits the PI3K/AKT signaling pathway to induce cell cycle arrest and apoptosis in cancer cells, and significantly suppresses the growth of HepG2 and PC-3 xenograft tumors in mice. Cucurbitacin C can be used in studies on plant defense mechanisms, secondary metabolism and cancer therapy. | ||||||||||||||||||||
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References
- [1]. Wu D, et al. Corrigendum: In vitro and in vivo antitumor activity of cucurbitacin C, a novel natural product from cucumber. Front Pharmacol. 2024 Mar 4;15:1334971.
- [2]. Liu Z, et al. The role of HS in low temperature-induced cucurbitacin C increases in cucumber. Plant molecular biology. 2019 Apr;99(6):535-544.
- [3]. Hideki HORIE, et al. Cucurbitacin C—Bitter Principle in Cucumber Plants, Japan Agricultural Research Quarterly: JARQ, 2007, Volume 41, Issue 1, Pages 65-68, Released on J-STAGE March 26, 2013, Online ISSN 2185-8896, Print ISSN 0021-3551,
- [4]. Liu, J, et al. Preliminary investigation of the anti-colon cancer activity of cucurbitacin C from cucumber: A network pharmacological study and experimental validation. Food Frontiers. 2024; 5, 142-159.
- [5]. Balkema-Boomstra AG, et al. Role of cucurbitacin C in resistance to spider mite (Tetranychus urticae) in cucumber (Cucumis sativus L.). Journal of chemical ecology. 2003 Jan;29(1):225-35.
