603-11-2
Chemical Structure
3-Nitrophthalic acid
Synonym(s): m-Nitrophthalic acid; o-Nitrophthalic acid; 3-Nitrophthalic acid
- CAS No.: 603-11-2
- Formula:C8H5NO6
- Molecular Weight:211.13
IUPAC Name: 3-nitrophthalic acid
InChIKey: KFIRODWJCYBBHY-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC([N+]([O-])=O)=C1C(O)=O)O
Biological Activity: 3-Nitrophthalic acid (m-Nitrophthalic acid) is a nitro-substituted aromatic carboxylic acid that acts as a DPPH radical scavenger through hydrogen donation. 3-Nitrophthalic acid induces cellular oxidative stress and Apoptosis. 3-Nitrophthalic acid inhibits NRF2/HO-1 antioxidant signaling and impairs follicular development and ovulation. 3-Nitrophthalic acid can be used to construct functional MOF. 3-Nitrophthalic acid can be used in the study of premature ovarian insufficiency[1][2][3][4].
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3-Nitrophthalic acid | 99.95% | 3-Nitrophthalic acid (m-Nitrophthalic acid) is a nitro-substituted aromatic carboxylic acid that acts as a DPPH radical scavenger through hydrogen donation. 3-Nitrophthalic acid induces cellular oxidative stress and Apoptosis. 3-Nitrophthalic acid inhibits NRF2/HO-1 antioxidant signaling and impairs follicular development and ovulation. 3-Nitrophthalic acid can be used to construct functional MOF. 3-Nitrophthalic acid can be used in the study of premature ovarian insufficiency. | ||||||||||||||||||||
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References
- [1]. Olmo F, et al. Synthesis and evaluation of in vitro and in vivo trypanocidal properties of a new imidazole-containing nitrophthalazine derivative. European journal of medicinal chemistry. 2015 Dec 01;106:106-19.
- [2]. Singaravelan K, et al. Hydrogen bonded charge transfer molecular salt (4-chloro anilinium-3-nitrophthalate) for photophysical and pharmacological applications. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2017 Sep 5;184:318-26.
- [3]. Mo L, et al. Rescues 3-NPA-Induced Defective Follicular Development via Modulating the NRF2/HO-1 Signaling Pathway in Granulosa Cells. Antioxidants (Basel, Switzerland). 2025 Jun 27;14(7):794. [Content Brief]
- [4]. Lu X, et al. Synthesis, structure, magnetism and antibacterial properties of a 2-D nickel (II) metal–organic framework based on 3-nitrophthalic acid and 4, 4′-bipyridine. Journal of Coordination Chemistry. 2014 Apr 3;67(7):1133-40.
