6049-57-6
Chemical Structure
Ethylmalonyl-CoA
Synonym(s): Ethylmalonyl coenzyme A
- CAS No.: 6049-57-6
- Formula:C26H42N7O19P3S
- Molecular Weight:881.63
IUPAC Name: 2-(((2-(3-((2R)-4-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl)thio)carbonyl)butanoic acid
InChIKey: VUGZQVCBBBEZQE-MIZDRFBCSA-N
SMILES: OC(C(CC)C(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(O)(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1OP(O)(O)=O)=O)(O)=O)=O)=O)=O)=O
Biological Activity: Ethylmalonyl-CoA (Ethylmalonyl coenzyme A) is a metabolic intermediate and biosynthetic precursor associated with crotonyl-CoA carboxylase/reductase. Ethylmalonyl‑CoA is generated via the reductive carboxylation of crotonyl-CoA catalyzed by crotonyl-CoA carboxylase/reductase (CCR); it can be recognized by the PKS acyltransferase AT and participate in the biosynthesis of antibiotic polyketide natural products. Ethylmalonyl-CoA is used in biosynthesis-related research[1][2].
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Ethylmalonyl-CoA | Ethylmalonyl-CoA (Ethylmalonyl coenzyme A) is a metabolic intermediate and biosynthetic precursor associated with crotonyl-CoA carboxylase/reductase. Ethylmalonyl‑CoA is generated via the reductive carboxylation of crotonyl-CoA catalyzed by crotonyl-CoA carboxylase/reductase (CCR); it can be recognized by the PKS acyltransferase AT and participate in the biosynthesis of antibiotic polyketide natural products. Ethylmalonyl-CoA is used in biosynthesis-related research. | |||||||||||||||||||||
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References
- [1]. Erb TJ, et al. Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway. Proceedings of the National Academy of Sciences of the United States of America. 2007 Jun 19;104(25):10631-6.
- [2]. Wilson MC, et al. Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. Natural product reports. 2012 Jan;29(1):72-86.
