Ethylmalonyl-CoA
Ethylmalonyl-CoA (Ethylmalonyl coenzyme A) is a metabolic intermediate and biosynthetic precursor associated with crotonyl-CoA carboxylase/reductase. Ethylmalonyl‑CoA is generated via the reductive carboxylation of crotonyl-CoA catalyzed by crotonyl-CoA carboxylase/reductase (CCR); it can be recognized by the PKS acyltransferase AT and participate in the biosynthesis of antibiotic polyketide natural products. Ethylmalonyl-CoA is used in biosynthesis-related research.
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- CAS No.: 6049-57-6
- Formula: C26H42N7O19P3S
- Molecular Weight:881.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Ethylmalonyl‑CoA can be produced via the reductive carboxylation of acetyl-CoA-derived intermediates in cell extracts of Rhodobacter sphaeroides cultured with acetate as the aerobic substrate; it can also be catalyzed to undergo reverse decomposition by purified recombinant Rhodobacter sphaeroides crotonyl-CoA carboxylase/reductase[1][2].
Ethylmalonyl‑CoA serves as a key precursor for the biosynthesis of polyketide natural products including monensin A, sanglifehrin A, davilactone, and bacillomycin [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6049-57-6
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Molecular Weight 881.63
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Formula C26H42N7O19P3S
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SMILES
OC(C(CC)C(SCCNC(CCNC([C@H](O)C(C)(C)COP(OP(O)(OC[C@H]1O[C@@H](N(C=N2)C3=C2C(N)=NC=N3)[C@H](O)[C@@H]1OP(O)(O)=O)=O)(O)=O)=O)=O)=O)=O
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Synonyms
Ethylmalonyl coenzyme A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ethylmalonyl-CoA Related Classifications
HY-126955 Related Classifications
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Keywords
- Ethylmalonyl-CoA
- 6049-57-6
- Ethylmalonyl coenzyme A
- Endogenous Metabolite
- crotonyl-CoA carboxylase/reductase
- Rhodobacter sphaeroides
- Streptomyces species
- acetyl-CoA
- methylotrophic bacteria
- isocitrate lyase-negative bacteria
- monensin A
- ethylmalonyl-CoA pathway
- polyketide synthase
- sanglifehrin A
- Inhibitor
- inhibitor
- inhibit