60508-89-6
Chemical Structure
Gonyautoxin II
- CAS No.: 60508-89-6
- Formula:C10H17N7O8S
- Molecular Weight:395.35
IUPAC Name: (3aS,4R,9R,10aS)-2,6-diamino-4-((carbamoyloxy)methyl)-10,10-dihydroxy-3a,4,9,10-tetrahydro-1H,8H-pyrrolo[1,2-c]purin-9-yl hydrogen sulfate
InChIKey: ARSXTTJGWGCRRR-XXKOCQOQSA-N
SMILES: OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@H]1OS(=O)(O)=O)N)COC(N)=O)O
Biological Activity: Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease[1][2].
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Gonyautoxin II | Gonyautoxin II is a paralytic shellfish poisoning toxin. Gonyautoxin II can block of the voltage-gated sodium channels at axonal level, impeding nerve impulse propagation. Gonyautoxin II has killing activity against mouse neuroblastoma cells. Gonyautoxin II can be used for the researches of cancer and neurological disease. | |||||||||||||||||||||
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- [1]. Jellett JF, et al. Toxicological evaluation of saxitoxin, neosaxitoxin, gonyautoxin II, gonyautoxin II plus III and decarbamoylsaxitoxin with the mouse neuroblastoma cell bioassay. Toxicol In Vitro. 1995 Feb;9(1):57-65. [Content Brief]
- [2]. Walker JR, et al. Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid. Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1689-1693. [Content Brief]
Keywords
