606-06-4
Chemical Structure
Coenzyme Q2
- CAS No.: 606-06-4
- Formula:C19H26O4
- Molecular Weight:318.41
IUPAC Name: (E)-2-(3,7-dimethylocta-2,6-dien-1-yl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
InChIKey: SQQWBSBBCSFQGC-JLHYYAGUSA-N
SMILES: O=C(C(C)=C(C1=O)C/C=C(C)/CC/C=C(C)\C)C(OC)=C1OC
Biological Activity: Coenzyme Q2 is a benzoquinone electron carrier in the mitochondrial electron transport chain and a p53-dependent apoptosis inducer. Coenzyme Q2 induces p53 phosphorylation at Ser15, promoting p53 accumulation and functional activation. Coenzyme Q2 induces ROS generation, caspase-3 activation, DNA fragmentation, phosphatidylserine externalization, mitochondrial permeability transition pore opening, and oxidative phosphorylation uncoupling. Coenzyme Q2 inhibits Complex I, Complex III, and Complex IV activities, disrupting electron transport and membrane potential generation. Coenzyme Q2 induces excessive mitochondrial proton leak in forebrain mitochondria. Coenzyme Q2 causes loss of righting reflex in mice, accompanied by slow-wave delta EEG activity and reversible loss of wakefulness. Coenzyme Q2 inhibits lipid peroxidation and scavenges superoxide radicals. Coenzyme Q2 is used in research on leukemia, myocardial ischemia-reperfusion injury, and mitochondrial encephalomyopathy[1][2][3][4].
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Coenzyme Q2 | Coenzyme Q2 is a benzoquinone electron carrier in the mitochondrial electron transport chain and a p53-dependent apoptosis inducer. Coenzyme Q2 induces p53 phosphorylation at Ser15, promoting p53 accumulation and functional activation. Coenzyme Q2 induces ROS generation, caspase-3 activation, DNA fragmentation, phosphatidylserine externalization, mitochondrial permeability transition pore opening, and oxidative phosphorylation uncoupling. Coenzyme Q2 inhibits Complex I, Complex III, and Complex IV activities, disrupting electron transport and membrane potential generation. Coenzyme Q2 induces excessive mitochondrial proton leak in forebrain mitochondria. Coenzyme Q2 causes loss of righting reflex in mice, accompanied by slow-wave delta EEG activity and reversible loss of wakefulness. Coenzyme Q2 inhibits lipid peroxidation and scavenges superoxide radicals. Coenzyme Q2 is used in research on leukemia, myocardial ischemia-reperfusion injury, and mitochondrial encephalomyopathy. | |||||||||||||||||||||
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References
- [1]. Esaka Y, et al. Coenzyme Q2 induced p53-dependent apoptosis. Biochimica et biophysica acta. 2005 Jun 20;1724(1-2):49-58.
- [2]. Lim H, et al. Sedative-hypnotic properties and mitochondrial effects of coenzyme Q2 in mice. Current molecular pharmacology. 2025;18(1):100-107.
- [3]. Gharib A, et al. Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: role of complex I. Journal of molecular and cellular cardiology. 2012 May;52(5):1091-5.
- [4]. Beyer RE, et al. The participation of coenzyme Q in free radical production and antioxidation. Free radical biology & medicine. 1990;8(6):545-65.
