61468-88-0
61468-88-0
Chemical Structure
2'-NH2-ATP
Synonym(s): 2'-Amino-2'-deoxyadenosine-5'-triphosphate
- CAS No.: 61468-88-0
- Formula:C10H17N6O12P3
- Molecular Weight:506.20
IUPAC Name: ((2R,3S,4R,5R)-4-amino-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: BPRNAIIYYOQQKN-QYYRPYCUSA-N
SMILES: OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](N)[C@@H]1O)(O)=O)(OP(O)(O)=O)=O
Biological Activity: 2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a Ki of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling[1][2][3].
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2'-NH2-ATP | 2'-NH2-ATP (2'-Amino-2'-deoxyadenosine-5'-triphosphate), an adenosine derivative, is a weak competitive inhibitor of ATP, with a Ki of 2.3 mM. 2'-NH2-ATP can be used in nucleic acid labeling. | |||||||||||||||||||||
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References
- [1]. Armstrong VW, et, al. Interaction of substrate analogues with Escherichia coli DNA-dependent RNA polymerase. Eur J Biochem. 1976 Nov 1;70(1):33-8. [Content Brief]
- [2]. Faylene A. L. KINETIC STUDIES ON WILD-TYPE AND MUTANT ESCHERICHIA COLICYTIDINE 5'-TRIPHOSPHATE SYNTHASES AND INHIBITOR DEVELOPMENT. Dalhousie University Halifax, Nova Scotia. 2008 Jul.
- [3]. Aström H, et, al. Acidity of secondary hydroxyls in ATP and adenosine analogues and the question of a 2',3'-hydrogen bond in ribonucleosides. J Am Chem Soc. 2004 Nov 17;126(45):14710-1. [Content Brief]
