618361-63-0
Chemical Structure
ZINC08383544
- CAS. Nr.: 618361-63-0
- Formula:C30H30N2O6
- Molecular Weight:514.58
IUPAC Name: 4-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbonyl)-3-hydroxy-5-(4-(pentyloxy)phenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
InChIKey: UEEMPANMROSHCK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2OCCOC2=C1)C3=C(O)C(=O)N(CC=4C=NC=CC4)C3C5=CC=C(OCCCCC)C=C5
Biological Activity: ZINC08383544 is a PKM2 activator with anti-tumor activity. ZINC08383544 binds to the dimer-dimer interface of PKM2, promotes tetramer formation, blocks nuclear translocation, inhibits the expression of glycolysis-related genes such as GLUT1, and reduces T cell-mediated inflammatory responses. ZINC08383544 can be used in cancer-related research such as cervical cancer[1].
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ZINC08383544 | ZINC08383544 is a PKM2 activator with anti-tumor activity. ZINC08383544 binds to the dimer-dimer interface of PKM2, promotes tetramer formation, blocks nuclear translocation, inhibits the expression of glycolysis-related genes such as GLUT1, and reduces T cell-mediated inflammatory responses. ZINC08383544 can be used in cancer-related research such as cervical cancer. | |||||||||||||||||||||
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