62040-55-5
Chemical Structure
4-Amino-L-phenylalanine hydrochloride
Synonym(s): H-Phe(4-NH2)-OH hydrochloride
- CAS No.: 62040-55-5
- Formula:C9H13ClN2O2
- Molecular Weight:216.66
IUPAC Name: (S)-2-amino-3-(4-aminophenyl)propanoic acid hydrochloride
InChIKey: ISCZSPZLBJLJGO-QRPNPIFTSA-N
SMILES: NC1=CC=C(C[C@H](N)C(O)=O)C=C1.Cl
Biological Activity: 4-Amino-L-phenylalanine hydrochloride (H-Phe(4-NH2)-OH) is a metabolic intermediate and an α-carbonic anhydrase (TcCA) activator with a Ka value of 0.75 μM. 4-Amino-L-phenylalanine hydrochloride acts through active site cavity entrance binding and a proton shuttle mechanism to enhance the catalytic rate of CO2 hydration. 4-Amino-L-phenylalanine hydrochloride serves as a diamine monomer for bio-based polymer synthesis and is produced in Escherichia coli via the shikimate pathway. 4-Amino-L-phenylalanine hydrochloride constitutes a structural component of haptens used in immunoassay development. 4-Amino-L-phenylalanine hydrochloride is used for the production of Chloramphenicol (HY-B0239) and Pristinamycin I in Streptomyces venezuelae and S. pristinaespiralis, respectively. 4-Amino-L-phenylalanine hydrochloride is used in research related to Trypanosoma cruzi infection[1][2][3].
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4-Amino-L-phenylalanine hydrochloride | 4-Amino-L-phenylalanine hydrochloride (H-Phe(4-NH2)-OH) is a metabolic intermediate and an α-carbonic anhydrase (TcCA) activator with a Ka value of 0.75 μM. 4-Amino-L-phenylalanine hydrochloride acts through active site cavity entrance binding and a proton shuttle mechanism to enhance the catalytic rate of CO2 hydration. 4-Amino-L-phenylalanine hydrochloride serves as a diamine monomer for bio-based polymer synthesis and is produced in Escherichia coli via the shikimate pathway. 4-Amino-L-phenylalanine hydrochloride constitutes a structural component of haptens used in immunoassay development. 4-Amino-L-phenylalanine hydrochloride is used for the production of Chloramphenicol (HY-B0239) and Pristinamycin I in Streptomyces venezuelae and S. pristinaespiralis, respectively. 4-Amino-L-phenylalanine hydrochloride is used in research related to Trypanosoma cruzi infection. | |||||||||||||||||||||
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References
- [1]. Kawaguchi H, et al. Metabolic engineering for 4-aminophenylalanine production from lignocellulosic biomass by recombinant Escherichia coli. RSC Sustainability, 2023, 1(4): 1043-1054.
- [2]. Angeli A, et al. Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi. Bioorganic & medicinal chemistry. 2018 Aug 07;26(14):4187-4190.
- [3]. Shan G, et al. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chemical research in toxicology. 1999 Nov;12(11):1033-41.
