63026-02-8
63026-02-8
Chemical Structure
Crenulatin
- CAS No.: 63026-02-8
- Formula:C11H20O6
- Molecular Weight:248.27
IUPAC Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-((2-methylbut-3-en-2-yl)oxy)tetrahydro-2H-pyran-3,4,5-triol
InChIKey: ZEGGZNOPAPRAIG-SPFKKGSWSA-N
SMILES: CC(C=C)(C)O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)CO
Biological Activity: Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity[1][2][3].
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Crenulatin | 99.85% | Crenulatin is a gallotannin that can be isolated from Rhodiola rosea. Crenulatin can be used as a biomarker to identify potentially adulterated R. rosea products. Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, via regulating Fas/Bcl-2 expression and caspase-3 activity. | ||||||||||||||||||||
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References
- [1]. Marchev AS, et al. Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR-spectroscopy and HPLC. Phytochem Anal. 2020 Nov;31(6):756-769. [Content Brief]
- [2]. W S Yu, et al. Polyphenols from Rhodiola crenulata. Planta Med. 1993 Feb;59(1):80-2. [Content Brief]
- [3]. Qian R, et al. Dual-direction effect of crenulatin on apoptosis of cerebral microvascular endothelial cells and it's mechanism[J]. Chinese Journal of Pathophysiology, 2005: 2086-2090.
