63121-00-6
63121-00-6
Chemical Structure
(rel)-Oxaliplatin
- CAS No.: 63121-00-6
- Formula:C8H14N2O4Pt
- Molecular Weight:397.29
InChIKey: ZROHGHOFXNOHSO-BNTLRKBRSA-L
SMILES: O=C1[O-][Pt+2]2([O-]C1=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]2
Biological Activity: (rel)-Oxaliplatin is a DNA synthesis inhibitor. (rel)-Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. (rel)-Oxaliplatin can be used for cancer research[1][2][3].
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(rel)-Oxaliplatin | (rel)-Oxaliplatin is a DNA synthesis inhibitor. (rel)-Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. (rel)-Oxaliplatin can be used for cancer research. | |||||||||||||||||||||
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References
- [1]. Woynarowski JM, et, al. Oxaliplatin-induced damage of cellular DNA. Mol Pharmacol. 2000 Nov;58(5):920-7. [Content Brief]
- [2]. Wang Z, et, al. Oxaliplatin induces apoptosis in hepatocellular carcinoma cells and inhibits tumor growth. Expert Opin Investig Drugs. 2009 Nov;18(11):1595-604. [Content Brief]
- [3]. Pendyala L, et, al. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res. 1993 Dec 15;53(24):5970-6. [Content Brief]
