635-39-2
Chemical Structure
Guanine hydrochloride
- CAS No.: 635-39-2
- Formula:C5H6ClN5O
- Molecular Weight:187.59
IUPAC Name: 2-amino-3,7-dihydro-6H-purin-6-one hydrochloride
InChIKey: IBAOFQIOOBQLHE-UHFFFAOYSA-N
SMILES: O=C1N=C(N)NC2=C1NC=N2.Cl
Biological Activity: Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). Guanine hydrochloride is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity N pool. Guanine hydrochloride has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4].
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Guanine hydrochloride | 98.78% | Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). Guanine hydrochloride is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity N pool. Guanine hydrochloride has cytotoxic, antinociceptive and neuroprotective effects. | ||||||||||||||||||||
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- [1]. Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020;117(51):32722-32730. [Content Brief]
- [2]. Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016;59(23):10763-10773. [Content Brief]
- [3]. Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004;108(6):812-817. [Content Brief]
- [4]. de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016;772:71-82. [Content Brief]
Keywords
