63798-73-2
Chemical Structure
Cyclosporin E
Synonym(s): 11-Demethylcyclosporin A
- CAS No.: 63798-73-2
- Formula:C61H109N11O12
- Molecular Weight:1188.58
IUPAC Name: (3S,6R,9S,12S,15S,18S,24S,30S,33S)-24-ethyl-27-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-3,12,18,33-tetraisobutyl-15,30-diisopropyl-1,4,6,9,13,19,22,28-octamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
InChIKey: SYXYUKMELXLDBD-QOMVXLFYSA-N
SMILES: C/C=C/C[C@@H](C)[C@H]([C@]1([H])N(C([C@@H](NC([C@@H](N(C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)CC(C)C)=O)C(C)C)=O)C)O
Biological Activity: Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide that can be isolated from fungi such as TTrichoderma polysporum and other imperfect fungi. Cyclosporin E belongs to the Cyclosporins family. Cyclosporin E can be used for studying the structure-activity relationships and molecular dynamic properties of cyclosporin compounds. As a structural control compound, Cyclosporin E holds significant research value in the fields of medicinal chemistry and biophysics[1][2].
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Cyclosporin E | Cyclosporin E (11-Demethylcyclosporin A) is a cyclic oligopeptide that can be isolated from fungi such as TTrichoderma polysporum and other imperfect fungi. Cyclosporin E belongs to the Cyclosporins family. Cyclosporin E can be used for studying the structure-activity relationships and molecular dynamic properties of cyclosporin compounds. As a structural control compound, Cyclosporin E holds significant research value in the fields of medicinal chemistry and biophysics. | |||||||||||||||||||||
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- [1]. Traber R, et al. Neue Cyclopeptide aus Trichoderma polysporum (LINK EX PERS.) RIFAI: die Cyclosporine B, D und E [New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E (author's transl)]. Helv Chim Acta. 1977;60(5):1568-78. German. [Content Brief]
- [2]. Kobchikova P P, et al. Features of spatial structures of cyclosporins D, E and G revealed by NMR and MD simulations[J]. Journal of Molecular Liquids, 2021, 336: 116244.
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