64099-44-1
Chemical Structure
Quisultidine
Synonym(s): LM 24056
- CAS No.: 64099-44-1
- Formula:C21H25N3O2S2
- Molecular Weight:415.57
IUPAC Name: N,N-dimethyl-10-(quinuclidin-3-yl)-10H-phenothiazine-2-sulfonamide
InChIKey: HTHHBTMNLHMBHQ-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(SC2=C3C=CC=C2)C(N3C4CN5CCC4CC5)=C1)(N(C)C)=O
Biological Activity: Quisultidine (LM 24056) is an orally active phenothiazine derivative with both calmodulin (Calmodulin) inhibitory activity (with a IC50 of 55 μM against porcine calmodulin) and muscarinic acetylcholine receptor (mAChR) ligand activity (with a IC50 of 400 nM). It inhibits gastric acid and pepsin secretion, reduces circulating gastrin levels, and blocks histamine-stimulated gastric acid secretion. Quisultidine can be used in the research of duodenal ulcer[1][2][3][4][5][6][7].
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Quisultidine | Quisultidine (LM 24056) is an orally active phenothiazine derivative with both calmodulin (Calmodulin) inhibitory activity (with a IC50 of 55 μM against porcine calmodulin) and muscarinic acetylcholine receptor (mAChR) ligand activity (with a IC50 of 400 nM). It inhibits gastric acid and pepsin secretion, reduces circulating gastrin levels, and blocks histamine-stimulated gastric acid secretion. Quisultidine can be used in the research of duodenal ulcer. | |||||||||||||||||||||
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References
- [1]. Wilson JA, et al. Effects of some polycyclic drugs on gastric secretion and on the healing of duodenal ulcers. Acta psychiatrica Scandinavica. Supplementum. 1985;320:93-7.
- [2]. Wilson JA, et al. Inhibition of pentagastrin-stimulated and overnight gastric secretion by mianserin. British journal of clinical pharmacology. 1983;15 Suppl 2(Suppl 2):329S-333S.
- [3]. Kauffmann JM, et al. Electrochemical behaviour at solid electrodes and metabolic fate of drugs. Contemporary electroanalytical chemistry. Boston, MA: Springer US, 1990. 373-378.
- [4]. Kauffmann JM, et al. Unusual electrochemical behaviour of a new phenothiazine. Analyst. 1985 Apr;110(4):349-51.
- [5]. Mizoule J, et al. On the long acting gastric antisecretory activity of LM 24056 a non H2 antagonist. Life sciences. 1982 Oct 04;31(14):1473-85.
- [6]. Vatier J, et al. The antigastrinic effect of a phenothiazine (LM 24056) prevents gastric secretory activity of histamine. Agents and actions. 1986 Nov;19(3-4):174-9.
- [7]. Merritt JE, et al. The relationship between prolactin secretion and calmodulin activity. The Journal of endocrinology. 1983 Sep;98(3):423-9.
