64192-56-9
64192-56-9
Chemical Structure
U-51605
- CAS No.: 64192-56-9
- Formula:C20H32N2O2
- Molecular Weight:332.48
IUPAC Name: (Z)-7-((1R,4S,5R,6R)-6-((E)-oct-1-en-1-yl)-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl)hept-5-enoic acid
InChIKey: SRIZDZJPKIYUPZ-IDUFWMFESA-N
SMILES: OC(CCC/C=C\C[C@@H]1[C@H]([C@@]2([H])C[C@]1([H])N=N2)/C=C/CCCCCC)=O
Biological Activity: U-51605 is a platelet aggregation inhibitor and inhibits thromboxane synthesis. U-51605 is also a prostaglandin I2 synthase inhibitor and can inhibit the retinal vasodilation response induced by NO donors (such as NOR3)[1][2].
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U-51605 | U-51605 is a platelet aggregation inhibitor and inhibits thromboxane synthesis. U-51605 is also a prostaglandin I2 synthase inhibitor and can inhibit the retinal vasodilation response induced by NO donors (such as NOR3). | |||||||||||||||||||||
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References
- [1]. Needleman P, Bryan B, Wyche A, et al. Thromboxane synthetase inhibitors as pharmacological tools: differential biochemical and biological effects on platelet suspensions[J]. Prostaglandins, 1977, 14(5): 897-907.
- [2]. Mori A, Namekawa R, Hasebe M, et al. Involvement of prostaglandin I2 in nitric oxide-induced vasodilation of retinal arterioles in rats[J]. European Journal of Pharmacology, 2015, 764: 249-255.
