6440-42-2
6440-42-2
Chemical Structure
Fluorphine
- CAS No.: 6440-42-2
- Formula:C20H22FN3O
- Molecular Weight:339.41
InChIKey: ZIGVSUYDKUDHPY-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N1C3CCN(C(C)C4=CC=C(C=C4)F)CC3)C=CC=C2
Biological Activity: Fluorphine is an analogue of Brorphine and can bind to μ-opioid receptor (MOR) (Ki: 12.5 nM). Fluorphine has GTPγS binding (EC50: 75 nM) and βarrestin 2 recruitment (EC50: 377 nM) activity. Fluorphine induces respiratory depressant effects[1][2].
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Fluorphine | Fluorphine is an analogue of Brorphine and can bind to μ-opioid receptor (MOR) (Ki: 12.5 nM). Fluorphine has GTPγS binding (EC50: 75 nM) and βarrestin 2 recruitment (EC50: 377 nM) activity. Fluorphine induces respiratory depressant effects. | |||||||||||||||||||||
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References
- [1]. Vandeputte MM, et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology. 2024 Dec 1;260:110113. [Content Brief]
- [2]. Kennedy NM, et al. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias. J Med Chem. 2018 Oct 11;61(19):8895-8907. [Content Brief]
Keywords
