6466-43-9
6466-43-9
Chemical Structure
TPBM
- CAS No.: 6466-43-9
- Formula:C15H16N4O2S
- Molecular Weight:316.38
IUPAC Name: 8-((benzylthio)methyl)-1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione
InChIKey: FEHAMBYTUPDFJE-UHFFFAOYSA-N
SMILES: O=C(N1C)N(C)C2=C(N=C(CSCC3=CC=CC=C3)N2)C1=O
Biological Activity: TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth[1].
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TPBM | 98.51% | TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for 17β-estradiol (E2)-ERα. TPBM reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TPBM inhibits E2-dependent growth of ERα-positive cancer cells (IC50=5 μM). TPBM is not toxic to cells and does not affect estrogen-independent cell growth. | ||||||||||||||||||||
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