6474-90-4

Tetrahydroalstonine Chemical Structure
6474-90-4

Chemical Structure

Tetrahydroalstonine

Synonym(s): (-)-Tetrahydroalstonine

  • CAS No.: 6474-90-4
  • Formula:C21H24N2O3
  • Molecular Weight:352.43

IUPAC Name: methyl (4S,4aS,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate

InChIKey: GRTOGORTSDXSFK-DLLGKBFGSA-N

SMILES: O=C(OC)C1=CO[C@@H](C)[C@@]2([H])[C@]1([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C2

Biological Activity: Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury[1][2][3].

Cat. No. Product Name Purity Description Pricing
HY-N1163 		Tetrahydroalstonine 99.84% Tetrahydroalstonine ((-)-Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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References

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