65425-48-1
Chemical Structure
AY 25674
- CAS No.: 65425-48-1
- Formula:C11H11NO4
- Molecular Weight:221.21
IUPAC Name: ethyl 2-oxo-2-((7-oxocyclohepta-1,3,5-trien-1-yl)amino)acetate
InChIKey: CRXULLXPVXXUJL-UHFFFAOYSA-N
SMILES: O=C(OCC)C(=O)NC1=CC=CC=CC1=O
Biological Activity: AY 25674 is an orally active antiallergic agent and a PDE inhibitor. AY 25674 inhibits the release of allergic histamine from mast cells. AY 25674 suppresses passive anaphylaxis induced by reaginic (IgE) antibodies. AY 25674 does not inhibit the increased vascular permeability caused by non-reaginic antibodies, serotonin or histamine. AY 25674 reaches its peak activity shortly after administration; rapid tolerance occurs at high doses. AY 25674 can be used in research related to passive anaphylaxis[1][2].
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AY 25674 | AY 25674 is an orally active antiallergic agent and a PDE inhibitor. AY 25674 inhibits the release of allergic histamine from mast cells. AY 25674 suppresses passive anaphylaxis induced by reaginic (IgE) antibodies. AY 25674 does not inhibit the increased vascular permeability caused by non-reaginic antibodies, serotonin or histamine. AY 25674 reaches its peak activity shortly after administration; rapid tolerance occurs at high doses. AY 25674 can be used in research related to passive anaphylaxis. | |||||||||||||||||||||
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- [1]. Pugsley T A, Lippmann W. Effects of [N-(2-oxo-3, 5, 7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3′, 5′-nucleotide formation and phosphodiesterase activity[J]. Experientia, 1979, 35(1): 88-90.
- [2]. Martel PR, et al. Inhibition of passive anaphylaxis induced in the rat hind paw and peritoneal cavity by N-(2-oxo-3,5,7-cycloheptatrien-1-yl)-aminooxoacetic acid ethyl ester (AY-25,674). Can J Physiol Pharmacol. 1978;56(6):1005-1010. [Content Brief]
Keywords
