65474-79-5
Chemical Structure
3-Hydroxymethyl-β-carboline
- CAS No.: 65474-79-5
- Formula:C12H10N2O
- Molecular Weight:198.22
IUPAC Name: (9H-pyrido[3,4-b]indol-3-yl)methanol
InChIKey: CPBYHTDUBNSBQM-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C3=C(C=NC(=C3)CO)N2
Biological Activity: 3-Hydroxymethyl-β-carboline is a Benzodiazepine antagonist with a Ki value of ~1470 nM. 3-Hydroxymethyl-β-carboline reverses Flurazepam-induced sleep, cerebrovascular and cerebral metabolic inhibition, and also partially reverses Flurazepam-induced decreases in blood pressure and heart rate. 3-Hydroxymethyl-β-carboline disrupts the anticonvulsant and anxiolytic effects of Diazepam in male mice. 3-Hydroxymethyl-β-carboline has no effect on sodium-dependent high-affinity choline uptake in rat cortical or hippocampal synaptosomes[1][2][3].
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3-Hydroxymethyl-β-carboline | 3-Hydroxymethyl-β-carboline is a Benzodiazepine antagonist with a Ki value of ~1470 nM. 3-Hydroxymethyl-β-carboline reverses Flurazepam-induced sleep, cerebrovascular and cerebral metabolic inhibition, and also partially reverses Flurazepam-induced decreases in blood pressure and heart rate. 3-Hydroxymethyl-β-carboline disrupts the anticonvulsant and anxiolytic effects of Diazepam in male mice. 3-Hydroxymethyl-β-carboline has no effect on sodium-dependent high-affinity choline uptake in rat cortical or hippocampal synaptosomes. | |||||||||||||||||||||
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- [1]. Hoffman WE, et al. Cerebrovascular and cerebral metabolic effects of flurazepam and a benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline. Eur J Pharmacol. 1984 Nov 27;106(3):585-91. [Content Brief]
- [2]. Skolinick P, et al. 3-hydroxymethyl-beta-carboline antagonizes some pharmacologic actions of diazepam. Eur J Pharmacol. 1981 Feb 19;69(4):525-7. [Content Brief]
- [3]. Miller JA, et al. The regulation of high-affinity choline uptake in vitro in rat cortical and hippocampal synaptosomes by beta-carbolines administered in vivo. Neurosci Lett. 1990 Jul 13;114(3):351-5. [Content Brief]
Keywords
