655234-81-4
655234-81-4
Chemical Structure
FTI-2628
- CAS No.: 655234-81-4
- Formula:C31H34N4O3S
- Molecular Weight:542.69
InChIKey: UIOVGRXEBWMUQT-LJAQVGFWSA-N
SMILES: O=C(OCC1=CC=CC=C1)[C@H](CCSC)NC(C2=C(C3=C(C=CC=C3)C)C=C(C=C2)CNCC4=CN=CN4)=O
Biological Activity: FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC50 of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FTI-2628 | FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC50 of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Ohkanda J, et al. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of medicinal chemistry. 2004 Jan 15;47(2):432-45. [Content Brief]
- [2]. Matti A, et al. Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets. 2012 Jan-Feb;4(1):74-7. [Content Brief]
