FTI-2628
FTI-2628 is an antimalarial agent and a farnesyl transferase inhibitor, with an IC50 of 41.7 nM against TbPET. FTI-2628 attenuates glucose-stimulated insulin secretion. FTI-2628 exhibits antimalarial activity against Trypanosoma brucei.
For research use only. We do not sell to patients.
- CAS No.: 655234-81-4
- Formula: C31H34N4O3S
- Molecular Weight:542.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Trypanosoma |
Chemical Information
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CAS No. 655234-81-4
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Molecular Weight 542.69
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Formula C31H34N4O3S
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SMILES
O=C(OCC1=CC=CC=C1)[C@H](CCSC)NC(C2=C(C3=C(C=CC=C3)C)C=C(C=C2)CNCC4=CN=CN4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ohkanda J, et al. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of medicinal chemistry. 2004 Jan 15;47(2):432-45. [Content Brief]
[2]. Matti A, et al. Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells. Islets. 2012 Jan-Feb;4(1):74-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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