663625-18-1
Chemical Structure
Rhod-2 potassium
- CAS No.: 663625-18-1
- Formula:C40H39K3N4O11
- Molecular Weight:869.05
IUPAC Name: potassium 2,2'-((2-(2-(2-(bis(carboxylatomethyl)amino)-5-(3,6-bis(dimethylamino)xanthylium-9-yl)phenoxy)ethoxy)-4-methylphenyl)azanediyl)diacetate
InChIKey: ZFYWHSXZMYZBNV-UHFFFAOYSA-K
SMILES: CN(C1=CC2=C(C=C1)C(C(C=C3)=CC(OCCOC(C=C4C)=C(C=C4)N(CC(O[K])=O)CC(O[K])=O)=C3N(CC(O[K])=O)CC([O-])=O)=C(C=CC(N(C)C)=C5)C5=[O+]2)C
Biological Activity: Rhod-2 potassium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 potassium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift[1][2].
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Rhod-2 potassium | Rhod-2 potassium is a cell impermeant, red fluorescent calcium indicator. Rhod-2 potassium exhibits a significant shift in fluorescence intensity upon calcium binding (ex max=549 nm; calcium-free v. ex/em max=552/581 nm; calcium-bound). Unlike the UV-excitable indicators Fura-2 and Indo-1 (HY-D0121), there is no accompanying spectral shift. | |||||||||||||||||||||
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- [1]. Minta, et al. Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J. Biol. Chem. 264(14), 8171-8178 (1989).
- [2]. Maxwell JT, et al. A novel mechanism of tandem activation of ryanodine receptors by cytosolic and SR luminal Ca2+ during excitation-contraction coupling in atrial myocytes. J Physiol. 2017 Jun 15;595(12):3835-3845. [Content Brief]
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