66556-73-8
66556-73-8
Chemical Structure
BOC-FlFlF
Synonym(s): BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe
- CAS No.: 66556-73-8
- Formula:C44H59N5O8
- Molecular Weight:785.97
InChIKey: NGNZQSPFQJCBJQ-DWCHZDDLSA-N
SMILES: O=C(O)[C@H](CC1=CC=CC=C1)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CC(C)C)NC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)=O)=O)=O
Biological Activity: BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BOC-FlFlF | 98.31% | BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation. | ||||||||||||||||||||
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References
- [1]. Hayashi R, et al. Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH. Bioorg Med Chem. 2014 Aug 1;22(15):3824-8. [Content Brief]
- [2]. Stenfeldt AL, et al. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation. 2007 Dec;30(6):224-9. [Content Brief]
