6682-26-4
6682-26-4
Chemical Structure
Cyclobenzaprine N-oxide
- CAS No.: 6682-26-4
- Formula:C20H21NO
- Molecular Weight:291.39
IUPAC Name: 3-(5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine oxide
InChIKey: CWVULMRJHWMZLY-UHFFFAOYSA-N
SMILES: C[N+](C)([O-])CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13
Biological Activity: Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine[1][2][3].
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Cyclobenzaprine N-oxide | Cyclobenzaprine N-oxide is the tertiary amine metabolite of Cyclobenzaprine (HY-B0740) in liver particles. Cyclobenzaprine is a skeletal muscle relaxant and is active on the central nervous system. The liver cytosol from liver particles has reductase activity that can reduce Cyclobenzaprine N-oxide to the corresponding amine. | |||||||||||||||||||||
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Cyclobenzaprine N-oxide-d3 | Cyclobenzaprine N-oxide-d3 is the deuterium labeled Cyclobenzaprine N-oxide. | |||||||||||||||||||||
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References
- [1]. Kitamura S, et al. Reduction of tertiary amine N-oxides by liver preparations: function of aldehyde oxidase as a major N-oxide reductase. Biochem Biophys Res Commun. 1984 Jun 29;121(3):749-54. [Content Brief]
- [2]. Kobayashi, et al. Ono, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems. Eur J Pharmacol, 1996. 311(1): p. 29-35. [Content Brief]
- [3]. Belvedere G, et al. Identification of cyclobenzaprine-10, 11-epoxide and other metabolites after incubation of cyclobenzaprine with rat liver microsomes[J]. Xenobiotica, 1975, 5(12): 765-771.
