66834-24-0
66834-24-0
Chemical Structure
Cianopramine
Synonym(s): Cyanimipramine; Ro 11-2465
- CAS No.: 66834-24-0
- Formula:C20H23N3
- Molecular Weight:305.42
IUPAC Name: 5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenzo[b,f]azepine-3-carbonitrile
InChIKey: LQXYCDLHSKICDY-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2C(N(CCCN(C)C)C3=CC=CC=C3CC2)=C1
Biological Activity: Cianopramine (Cyanimipramine) is a tricyclic antidepressant, and a potent inhibitor of neuronal serotonin (5-HT) uptake. Cianopramine blocks central and peripheral 5-HT receptors[1][2].
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Cianopramine | Cianopramine (Cyanimipramine) is a tricyclic antidepressant, and a potent inhibitor of neuronal serotonin (5-HT) uptake. Cianopramine blocks central and peripheral 5-HT receptors. | |||||||||||||||||||||
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References
- [1]. Eichler HG, et al. Effect of cianopramine, a tricyclic antidepressant, on platelet serotonin uptake and peripheral adrenergic function. Clin Pharmacol Ther. 1984 Oct;36(4):542-5. [Content Brief]
- [2]. Pawlowski L, et al. Ro 11-2465 (cyan-imipramine), citalopram and their N-desmethyl metabolites: effects on the uptake of 5-hydroxytryptamine and noradrenaline in vivo and related pharmacological activities. Psychopharmacology (Berl). 1985;86(1-2):156-63. [Content Brief]
