66866-63-5
Chemical Structure
Lutrelin
Synonym(s): Wy 40972
- CAS No.: 66866-63-5
- Formula:C65H85N17O12
- Molecular Weight:1296.48
IUPAC Name: (S)-N-ethyl-1-(N-methyl-N-((S)-5-oxopyrrolidine-2-carbonyl)-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl)pyrrolidine-2-carboxamide
InChIKey: YGGIRYYNWQICCP-LDRBRYNMSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC([C@@H]2CCC(N2)=O)=O)CC3=CN=CN3)=O)CC4=CNC5=CC=CC=C45)=O)=O)C(N[C@@H](C(N(C)[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N6[C@@H](CCC6)C(NCC)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O
Biological Activity: Lutrelin (Wy 40972) is a luteinizing hormone releasing hormone (LHRH) agonist. Lutrelin inhibits the growth of the endometrial expiant in rats[1][2].
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Lutrelin | Lutrelin (Wy 40972) is a luteinizing hormone releasing hormone (LHRH) agonist. Lutrelin inhibits the growth of the endometrial expiant in rats. | |||||||||||||||||||||
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- [1]. Habenicht UF, et al. Short-term effects of an LHRH-agonist alone or in combination with testosterone propionate or indomethacin on rat testes. Evidence of testosterone independent effects. I. Andrologia. 1987 Nov-Dec;19(6):602-13. [Content Brief]
- [2]. Jones RC. The effect of a luteinizing hormone releasing hormone (LRH) agonist (Wy-40,972), levonorgestrel, danazol and ovariectomy on experimental endometriosis in the rat. Acta Endocrinol (Copenh). 1984 Jun;106(2):282-8. [Content Brief]
Keywords
