67450-44-6
67450-44-6
Chemical Structure
Eclanamine
- CAS No.: 67450-44-6
- Formula:C16H22Cl2N2O
- Molecular Weight:329.26
InChIKey: YCRFSKUCDBJWLX-HUUCEWRRSA-N
SMILES: CCC(N(C1=CC(Cl)=C(C=C1)Cl)[C@H]2[C@@H](CCC2)N(C)C)=O
Biological Activity: Eclanamine is an orally effective non-tricyclic antidepressant and an adrenergic receptor modulator. Eclanamine blocks biogenic amine uptake and enhances α2-receptor sensitivity, and long-term administration induces downregulation and desensitization of cortical β-receptors. Eclanamine is used in the study of depression[1][2][3][4].
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Eclanamine | Eclanamine is an orally effective non-tricyclic antidepressant and an adrenergic receptor modulator. Eclanamine blocks biogenic amine uptake and enhances α2-receptor sensitivity, and long-term administration induces downregulation and desensitization of cortical β-receptors. Eclanamine is used in the study of depression. | |||||||||||||||||||||
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References
- [1]. Lakings DB, et al. High-performance liquid chromatographic method for the determination of eclanamine and its N-desmethyl and N,N-didesmethyl metabolites in urine. J Chromatogr. 1988 Jun 24;428(1):131-9.
- [2]. Aaron CS, et al. Risk and benefit evaluation in development of pharmaceutical products. Environ Health Perspect.
- [3]. Sethy VH, et al. Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants. Progress in neuro-psychopharmacology & biological psychiatry. 1988;12(5):673-82.
- [4]. Szmuszkovicz J, et al. A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds. J Med Chem. 1981 Oct;24(10):1230-6. [Content Brief]
