68284-69-5
Chemical Structure
Disobutamide
Synonym(s): SC-31828
- CAS No.: 68284-69-5
- Formula:C23H38ClN3O
- Molecular Weight:408.02
IUPAC Name: 2-(2-chlorophenyl)-4-(diisopropylamino)-2-(2-(piperidin-1-yl)ethyl)butanamide
InChIKey: YKFWMDHZMQLWBO-UHFFFAOYSA-N
SMILES: O=C(C(CCN(C(C)C)C(C)C)(CCN1CCCCC1)C2=CC=CC=C2Cl)N
Biological Activity: Disobutamide (SC-31828) is an orally active, blood-brain barrier permeable cationic amphiphilic ditertiary amine piperidine ring compound with antiarrhythmic properties. Disobutamide induces lysosomal phospholipid accumulation, which triggers extensive cytoplasmic vacuolization and leads to cell death. Disobutamide prolongs multiple electrocardiographic intervals in canine hearts, induces cardiac arrest at high doses, and causes decreased retinal reflectivity. Disobutamide can be used in studies related to arrhythmias, and also serves as a model drug for investigating the storage mechanisms and toxicity thresholds of intracellular amphiphilic compounds[1][2][3].
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Disobutamide | Disobutamide (SC-31828) is an orally active, blood-brain barrier permeable cationic amphiphilic ditertiary amine piperidine ring compound with antiarrhythmic properties. Disobutamide induces lysosomal phospholipid accumulation, which triggers extensive cytoplasmic vacuolization and leads to cell death. Disobutamide prolongs multiple electrocardiographic intervals in canine hearts, induces cardiac arrest at high doses, and causes decreased retinal reflectivity. Disobutamide can be used in studies related to arrhythmias, and also serves as a model drug for investigating the storage mechanisms and toxicity thresholds of intracellular amphiphilic compounds. | |||||||||||||||||||||
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- [1]. Ruben Z, et al. The susceptibility of various cultured cells to induction of clear cytoplasmic vacuoles by disobutamide[J]. Toxicology in vitro, 1990, 4(4-5): 497-505. [Content Brief]
- [2]. Ruben Z, et al. Disobutamide: a model agent for investigating intracellular drug storage[J]. Toxicology and applied pharmacology, 1989, 97(1): 57-71.
- [3]. Koizumi H, Watanabe M, Numata H, et al. Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey[J]. Toxicology and applied pharmacology, 1986, 84(1): 125-148. [Content Brief]
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