69014-14-8
69014-14-8
Chemical Structure
Tiotidine
Synonym(s): ICI 125211
- CAS No.: 69014-14-8
- Formula:C10H16N8S2
- Molecular Weight:312.42
InChIKey: YDDXVAXDYKBWDX-UHFFFAOYSA-N
SMILES: CN/C(NC#N)=N\CCSCC1=CSC(NC(N)=N)=N1
Biological Activity: Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors[1][2].
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Tiotidine | 98.09% | Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors. | ||||||||||||||||||||
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Tiotidine (Standard) | ≥98% | Tiotidine (Standard) is the analytical standard of Tiotidine. This product is intended for research and analytical applications. Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors. | ||||||||||||||||||||
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References
- [1]. Barth H, et al. Structural requirements of imidazole compounds to be inhibitors or activators of histaminemethyltransferase: investigation of histamine analogues and H2-receptor antagonists. [Content Brief]
- [2]. Trzeciakowski JP, et al. The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist. J Pharmacol Exp Ther. 1980 Sep;214(3):629-34. [Content Brief]
Keywords
