70010-76-3
70010-76-3
Chemical Structure
NE97220
- CAS No.: 70010-76-3
- Formula:C7H12N2O6P2
- Molecular Weight:282.13
IUPAC Name: (((3-methylpyridin-2-yl)amino)methylene)bis(phosphonic acid)
InChIKey: NAIJOBGUXRHQJW-UHFFFAOYSA-N
SMILES: O=P(O)(C(P(O)(O)=O)NC1=NC=CC=C1C)O
Biological Activity: NE97220 is a biochemical reagent. NE97220 induces macrophage apoptosis and reduces their viability, leading to internucleosomal DNA fragmentation. NE97220 inhibits the growth of Trypanosoma brucei rhodesiense. NE97220 is used in research on human African trypanosomiasis and immune-related studies[1][2][3][4].
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NE97220 | NE97220 is a biochemical reagent. NE97220 induces macrophage apoptosis and reduces their viability, leading to internucleosomal DNA fragmentation. NE97220 inhibits the growth of Trypanosoma brucei rhodesiense. NE97220 is used in research on human African trypanosomiasis and immune-related studies. | |||||||||||||||||||||
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References
- [1]. Luckman SP, et al. Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1998 Nov;13(11):1668-78.
- [2]. Räikkönen J, et al. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. Biochemical and biophysical research communications. 2011 Apr 22;407(4):663-7.
- [3]. Xie A, et al. Bisphosphonates. Internet Electronic Journal of Molecular Design. 2004;3:622-50.
- [4]. Ebrahimpour A, et al. Determination of solubility and calcium ion stability constants of a phosphonoalkylphosphinate (PAP) and bisphosphonates (BPs) such as EHDP, Risedronate, Alendronate, 3-pic AMBP, and 3-pic AMPMP. InMineral scale formation and inhibition 1995 (pp. 295-305). Boston, MA: Springer US.
