7057-27-4
Chemical Structure
3′-Deoxyuridine
- CAS No.: 7057-27-4
- Formula:C9H12N2O5
- Molecular Weight:228.20
IUPAC Name: 1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: QOXJRLADYHZRGC-SHYZEUOFSA-N
SMILES: O=C(N1)N([C@H]2[C@H](O)C[C@@H](CO)O2)C=CC1=O
Biological Activity: 3′-Deoxyuridine is a 3'-deoxynucleoside analog and a 2',3'-dideoxynucleoside. 3′-Deoxyuridine does not inhibit the replication of HCV-like RNA templates or luciferase levels in human cells at the tested concentrations. 3′-Deoxyuridine serves as a substrate for microbial dideoxyribosylation reactions to generate various 2',3'-dideoxynucleosides, but cannot be converted into 2',3'-dideoxycytidine by resting E. coli AJ 2595 cells. 3′-Deoxyuridine can be formed by the deamination of 3'-deoxycytidine by E. coli BM-11 cytidine deaminase, and can also undergo phosphorolytic cleavage to produce uracil and the corresponding pentose phosphate. 3′-Deoxyuridine has been used in research related to HCV and other relevant fields[1][2][3].
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3′-Deoxyuridine | 98.87% | 3′-Deoxyuridine is a 3'-deoxynucleoside analog and a 2',3'-dideoxynucleoside. 3′-Deoxyuridine does not inhibit the replication of HCV-like RNA templates or luciferase levels in human cells at the tested concentrations. 3′-Deoxyuridine serves as a substrate for microbial dideoxyribosylation reactions to generate various 2',3'-dideoxynucleosides, but cannot be converted into 2',3'-dideoxycytidine by resting E. coli AJ 2595 cells. 3′-Deoxyuridine can be formed by the deamination of 3'-deoxycytidine by E. coli BM-11 cytidine deaminase, and can also undergo phosphorolytic cleavage to produce uracil and the corresponding pentose phosphate. 3′-Deoxyuridine has been used in research related to HCV and other relevant fields. | ||||||||||||||||||||
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3′-Deoxyuridine (Standard) | ≥98% | 3′-Deoxyuridine (Standard) is the analytical standard of 3′-Deoxyuridine. This product is intended for research and analytical applications. 3′-Deoxyuridine is a potential anticancer and antiviral agent. 3'-deoxyuridine inhibits bovine diarrhoea virus (BVDV) production. | ||||||||||||||||||||
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References
- [1]. Shirae H, et al. Production of 2',3'-dideoxyadenosine and 2',3'-dideoxyinosine from 2',3'-dideoxyuridine and the corresponding purine bases by resting cells of Escherichia coli AJ 2595. Appl Environ Microbiol. 1989;55(2):419-424. [Content Brief]
- [2]. King RW, et al. Inhibition of the replication of a hepatitis C virus-like RNA template by interferon and 3'-deoxycytidine. Antivir Chem Chemother. 2002;13(6):363-370. [Content Brief]
- [3]. Barai V N, et al. Chemo-enzymatic synthesis of 3-deoxy-β-D-ribofuranosyl purines and study of their biological properties[J]. Nucleosides, Nucleotides and Nucleic Acids, 2003, 22(5-8): 751-753.
