71079-19-1
71079-19-1
Chemical Structure
Timegadine
Synonym(s): SR1368
- CAS No.: 71079-19-1
- Formula:C20H23N5S
- Molecular Weight:365.50
IUPAC Name: (E)-1-cyclohexyl-2-(2-methylquinolin-4-yl)-3-(thiazol-2-yl)guanidine
InChIKey: SQVNITZYWXMWOG-UHFFFAOYSA-N
SMILES: CC1=NC2=CC=CC=C2C(/N=C(NC3CCCCC3)/NC4=NC=CS4)=C1
Biological Activity: Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets.
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Timegadine | Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. | |||||||||||||||||||||
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