71301-82-1
Chemical Structure
(S)-3-Hydroxyphenylglycine
Synonym(s): (S)-3HPG
- CAS No.: 71301-82-1
- Formula:C8H9NO3
- Molecular Weight:167.16
IUPAC Name: (S)-2-amino-2-(3-hydroxyphenyl)acetic acid
InChIKey: DQLYTFPAEVJTFM-ZETCQYMHSA-N
SMILES: O=C(O)[C@@H](N)C1=CC=CC(O)=C1
Biological Activity: (S)-3-Hydroxyphenylglycine ((S)-3HPG) is a metabotropic glutamate receptor (mGluR) agonist with an EC50 of 98 μM in rats. (S)-3-Hydroxyphenylglycine stimulates phosphoinositide hydrolysis, inhibits ACPD-induced depolarization, and exerts weak agonistic and inhibitory effects on mGluR1-mediated signal transduction. (S)-3-Hydroxyphenylglycine selectively activates mGluR1/5, downregulates NMDA receptor channels, reduces NMDA whole-cell currents and intracellular Ca2+ accumulation, and induces rapid intracellular Ca2+ oscillations in cortical neurons[1][2][3].
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(S)-3-Hydroxyphenylglycine | 97.57% | (S)-3-Hydroxyphenylglycine ((S)-3HPG) is a metabotropic glutamate receptor (mGluR) agonist with an EC50 of 98 μM in rats. (S)-3-Hydroxyphenylglycine stimulates phosphoinositide hydrolysis, inhibits ACPD-induced depolarization, and exerts weak agonistic and inhibitory effects on mGluR1-mediated signal transduction. (S)-3-Hydroxyphenylglycine selectively activates mGluR1/5, downregulates NMDA receptor channels, reduces NMDA whole-cell currents and intracellular Ca2+ accumulation, and induces rapid intracellular Ca2+ oscillations in cortical neurons. | ||||||||||||||||||||
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References
- [1]. Birse EF, et al. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 1993 Feb;52(3):481-8. [Content Brief]
- [2]. Hayashi Y, et al. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1994 May;14(5 Pt 2):3370-7. [Content Brief]
- [3]. Yu SP, et al. Membrane-delimited modulation of NMDA currents by metabotropic glutamate receptor subtypes 1/5 in cultured mouse cortical neurons. The Journal of physiology. 1997 Mar 15;499 ( Pt 3)(Pt 3):721-32.
