71989-18-9
Chemical Structure
Fmoc-Glu(OtBu)-OH
- CAS No.: 71989-18-9
- Formula:C24H27NO6
- Molecular Weight:425.47
IUPAC Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid
InChIKey: OTKXCALUHMPIGM-FQEVSTJZSA-N
SMILES: O=C(OC(C)(C)C)CC[C@@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O
Biological Activity: Fmoc‑Glu(OtBu)‑OH is an Fmoc-protected L‑glutamic acid derivative. Fmoc‑Glu(OtBu)‑OH is also a glutamate receptor binding agent with blood-brain barrier penetration that stimulates endogenous glutamate release in brain slices. Fmoc-Glu(OtBu)-OH binds to endogenous glutamate receptor sites in brain membranes with a Kd of 1.50 μM. Fmoc‑Glu(OtBu)‑OH can be used in research on nervous system-related diseases and also serves as an intermediate for research related to organic synthesis[1][2][3].
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Fmoc-Glu(OtBu)-OH | 99.93% | Fmoc‑Glu(OtBu)‑OH is an Fmoc-protected L‑glutamic acid derivative. Fmoc‑Glu(OtBu)‑OH is also a glutamate receptor binding agent with blood-brain barrier penetration that stimulates endogenous glutamate release in brain slices. Fmoc-Glu(OtBu)-OH binds to endogenous glutamate receptor sites in brain membranes with a Kd of 1.50 μM. Fmoc‑Glu(OtBu)‑OH can be used in research on nervous system-related diseases and also serves as an intermediate for research related to organic synthesis. | ||||||||||||||||||||
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Fmoc-Glu(OtBu)-OH-15N | Fmoc-Glu(OtBu)-OH-15N is the 15N-labeled Fmoc-Glu(OtBu)-OH (HY-Y0134). Fmoc‑Glu(OtBu)‑OH is an Fmoc-protected L‑glutamic acid derivative. Fmoc‑Glu(OtBu)‑OH is also a glutamate receptor binding agent with blood-brain barrier penetration that stimulates endogenous glutamate release in brain slices. Fmoc-Glu(OtBu)-OH binds to endogenous glutamate receptor sites in brain membranes with a Kd of 1.50 μM. Fmoc‑Glu(OtBu)‑OH can be used in research on nervous system-related diseases and also serves as an intermediate for research related to organic synthesis. | |||||||||||||||||||||
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Fmoc-Glu(OtBu)-OH-13C5,15N | 96.86% | Fmoc-Glu(OtBu)-OH-13C5,15N is the 13C, 15N-labeled Fmoc-Glu(OtBu)-OH (HY-Y0134). Fmoc‑Glu(OtBu)‑OH is an Fmoc-protected L‑glutamic acid derivative. Fmoc‑Glu(OtBu)‑OH is also a glutamate receptor binding agent with blood-brain barrier penetration that stimulates endogenous glutamate release in brain slices. Fmoc-Glu(OtBu)-OH binds to endogenous glutamate receptor sites in brain membranes with a Kd of 1.50 μM. Fmoc‑Glu(OtBu)‑OH can be used in research on nervous system-related diseases and also serves as an intermediate for research related to organic synthesis. | ||||||||||||||||||||
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-
Similarity Score 1.00
HY-Y1844Fmoc-D-Glu(OtBu)-OH -
Similarity Score 0.99
HY-W008667(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoic acid hydrate -
Similarity Score 0.89
HY-W008256Fmoc-Glu(OMe)-OH -
Similarity Score 0.89
HY-Y1166N-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester -
Similarity Score 0.89
HY-Y1166SN-(9-Fluorenylmethoxycarbonyl)glutamic acid α-tert-butyl ester-13C5,15N -
Similarity Score 0.88
HY-W048733Fmoc-Asu(OtBu)-OH -
Similarity Score 0.87
HY-W013144Fmoc-D-Asp(OtBu)-OH -
Similarity Score 0.87
HY-Y1169SFmoc-Asp(OtBu)-OH-15N -
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References
- [1]. Jiang R, et al. Electron Acceptive Mass Tag for Mass Spectrometric Imaging-Guided Synergistic Targeting to Mice Brain Glutamate Receptors. ACS chemical neuroscience. 2019 Jan 16;10(1):757-767.
- [2]. Mandal PK, et al. Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3. Journal of medicinal chemistry. 2009 Oct 08;52(19):6126-41.
- [3]. Tegge W, et al. Synthesis of Peptides from α- and β-Tubulin Containing Glutamic Acid Side-Chain Linked Oligo-Glu with Defined Length. International journal of peptides. 2010;2010:189396.
