738-99-8
738-99-8
Chemical Structure
Antineoplastic agent-1
- CAS No.: 738-99-8
- Formula:C12H24N6O2P2
- Molecular Weight:346.31
IUPAC Name: piperazine-1,4-diylbis(di(aziridin-1-yl)phosphine oxide)
InChIKey: RWNNRGBCWXOVAC-UHFFFAOYSA-N
SMILES: O=P(N1CC1)(N2CCN(P(N3CC3)(N4CC4)=O)CC2)N5CC5
Biological Activity:
Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research[1][2].
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Antineoplastic agent-1 | Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research. |
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References
- [1]. Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22. [Content Brief]
- [2]. Jensen MR, et al. Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage. Hepatology. 1998 Aug;28(2):537-46. [Content Brief]
